Impacts of polymorphisms in drug-metabolizing enzyme and transporter genes on irinotecan toxicity and efficacy in Thai colorectal cancer patients

• Natthakul Akarapredee,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Writing – original draft

  Affiliation The M.Sc. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand

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• Chalirmporn Atasilp,

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Validation

  Affiliation Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand

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• Chonlaphat Sukasem,

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision

  Affiliations Department of Pathology, Division of Pharmacogenomics and Personalized Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, Laboratory for Pharmacogenomics, Clinical Pathology, Ramathibodi Hospital, Bangkok, Thailand

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• Pimonpan Jinda,

  Roles Data curation, Methodology

  Affiliations Department of Pathology, Division of Pharmacogenomics and Personalized Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, Laboratory for Pharmacogenomics, Clinical Pathology, Ramathibodi Hospital, Bangkok, Thailand

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• Rattanaporn Sukprasong,

  Roles Data curation, Methodology

  Affiliations Department of Pathology, Division of Pharmacogenomics and Personalized Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, Laboratory for Pharmacogenomics, Clinical Pathology, Ramathibodi Hospital, Bangkok, Thailand

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• Jiraporn Jensuriyarkun,

  Roles Data curation, Methodology

  Affiliation Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand

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• Soravit Wongjitjanyong,

  Roles Data curation, Methodology

  Affiliation Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand

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• Patompong Satapornpong,

  Roles Data curation, Methodology

  Affiliations Division of General Pharmacy Practice, Department of Pharmaceutical Care, College of Pharmacy, Rangsit University, Pathum Thani, Thailand, Excellence Pharmacogenomics and Precision Medicine Centre, College of Pharmacy, Rangsit University, Pathum Thani, Thailand

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• Natchaya Vanwong

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: natchaya.v@chula.ac.tac.th

  Affiliation Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand

  https://orcid.org/0000-0002-2230-3593

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