Impact of rAAV-shRNA treatment targeting mechanosensitive Ilk1 and Fermt2 in a mouse model of sepsis-induced muscle weakness

• Alexander Pacolet,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium, ADVANTAGE: Advanced Disease Modeling, Targeted Drug Discovery and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium

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• Inge Derese,

  Roles Data curation, Formal analysis

  Affiliation Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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• Lies Pauwels,

  Roles Data curation, Formal analysis

  Affiliation Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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• Sarah Vander Perre,

  Roles Data curation, Formal analysis

  Affiliation Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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• Maxime Smits,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

  Affiliation ADVANTAGE: Advanced Disease Modeling, Targeted Drug Discovery and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium

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• Chris Van den Haute,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation

  Affiliations Research Group for Neurobiology and Gene Therapy, Department of Neuroscience, KU Leuven, Leuven, Belgium, Leuven Viral Vector Core, Biomedical Sciences, KU Leuven, Leuven, Belgium

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• Sarah Derde,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration

  Affiliation Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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• Katrien Koppo,

  Roles Funding acquisition, Project administration, Supervision

  Affiliation Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium

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• Rik Gijsbers,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations ADVANTAGE: Advanced Disease Modeling, Targeted Drug Discovery and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, Leuven Viral Vector Core, Biomedical Sciences, KU Leuven, Leuven, Belgium

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• Lies Langouche

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lies.langouche@kuleuven.be

  Affiliation Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0002-8564-6809

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