Early skeletal muscle loss and clinical outcomes in critically ill patients in the medical intensive care unit: A retrospective cohort study

Soyun Kim; Da Hyun Kang; Dukki Kim; Soyoung Ahn; Mi Ra Lee; Song I Lee

doi:10.1371/journal.pone.0338315

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Open Access

Peer-reviewed

Research Article

Early skeletal muscle loss and clinical outcomes in critically ill patients in the medical intensive care unit: A retrospective cohort study

Soyun Kim,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea
⨯
Da Hyun Kang,

Roles Data curation, Writing – original draft

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea

https://orcid.org/0000-0002-3495-0931

⨯
Dukki Kim,

Roles Data curation, Writing – original draft

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea
⨯
Soyoung Ahn,

Roles Data curation, Writing – original draft

Affiliation Department of Rehabilitation Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea
⨯
Mi Ra Lee,

Roles Formal analysis, Supervision, Writing – original draft

Affiliation Division of Industrial Mathematics, Data Analytics Team, National Institute for Mathematical Sciences, Daejeon, Republic of Korea
⨯
Song I Lee

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: songi_cnu@cnu.ac.kr

Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea

https://orcid.org/0000-0001-8372-4511

⨯

Early skeletal muscle loss and clinical outcomes in critically ill patients in the medical intensive care unit: A retrospective cohort study

Soyun Kim,
Da Hyun Kang,
Dukki Kim,
Soyoung Ahn,
Mi Ra Lee,
Song I Lee

Published: December 18, 2025
https://doi.org/10.1371/journal.pone.0338315

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Intensive care units
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Skeletal muscles
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Muscle analysis
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Ultrasound imaging
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Death rates
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Bilirubin
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Muscle proteins
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Medical risk factors
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