Aotaphenazine, a rare hydrophenazine, targets topoisomerase II with anticancer efficacy: In silico to in vitro evidence

• Ahmed M. Metwaly ,

  Roles Conceptualization, Investigation, Project administration, Writing – original draft

  * E-mail: ametwaly@azhar.edu.eg (AHM); Ibrahimeissa@azhar.edu.eg (IHE)

  Affiliation Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  https://orcid.org/0000-0001-8566-1980

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• Ibrahim H. Eissa ,

  Roles Project administration, Software

  * E-mail: ametwaly@azhar.edu.eg (AHM); Ibrahimeissa@azhar.edu.eg (IHE)

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

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• Wael M. Afifi,

  Roles Investigation

  Affiliations Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt, Department of Pharmacognosy, Faculty of Pharmacy, Sinai University—Kantara Branch, Ismailia, Egypt

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• Eslam B. Elkaeed,

  Roles Investigation, Software

  Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia

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• Aisha A. Alsfouk,

  Roles Investigation

  Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

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• Ibrahim M. Ibrahim,

  Roles Software

  Affiliation Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt

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• Mohamed S. Abdelfattah

  Roles Methodology

  Affiliation Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt

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