Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV

• Chunchun Liu ,

  Contributed equally to this work with: Chunchun Liu, Yulei Ren, Xuan Luo

  Roles Investigation, Methodology, Writing – original draft

  * E-mail: liuchun880616@yeah.net (CL); danzhao5278@foxmail.com (DZ); yanghr@fudan.edu.cn (HY)

  Affiliation Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China

  https://orcid.org/0000-0002-4589-6192

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• Yulei Ren ,

  Contributed equally to this work with: Chunchun Liu, Yulei Ren, Xuan Luo

  Roles Software, Visualization

  Affiliation Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China

  https://orcid.org/0000-0002-3512-237X

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• Xuan Luo ,

  Contributed equally to this work with: Chunchun Liu, Yulei Ren, Xuan Luo

  Roles Methodology

  Affiliations Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

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• Peiyun Zhou,

  Roles Methodology

  Affiliation Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China

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• Xiangjuan Du,

  Roles Methodology

  Affiliation Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China

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• Qianmin Wang,

  Roles Software, Visualization

  Affiliation Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China

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• Xue Han,

  Roles Methodology, Software

  Affiliation Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China

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• Yanhui Xu,

  Roles Project administration, Supervision

  Affiliations Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China, The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Shanghai, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China

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• Ping Wang,

  Roles Methodology

  Affiliation Molinsights Biotechnologies, Guangdong Medical Valley Life Science Park, Guangzhou, China,

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• Dan Zhao ,

  Roles Methodology, Project administration

  * E-mail: liuchun880616@yeah.net (CL); danzhao5278@foxmail.com (DZ); yanghr@fudan.edu.cn (HY)

  Affiliations Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China

  https://orcid.org/0000-0002-4055-4214

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• Huirong Yang

  Roles Project administration, Supervision, Writing – review & editing

  * E-mail: liuchun880616@yeah.net (CL); danzhao5278@foxmail.com (DZ); yanghr@fudan.edu.cn (HY)

  Affiliations Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai, China, The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Shanghai, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China

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