Individual-level surrogacy of MRI lesions for disease severity in RRMS: Methods to quantify predictive power and their application to longitudinal data from recent trials

• Stefan Buchka ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

  * E-mail: sbuchka@ibe.med.uni-muenchen.de

  Affiliation Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany

  https://orcid.org/0000-0002-5453-3406

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• Joachim Havla,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, Munich, Germany

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• Begüm Irmak Ön,

  Roles Conceptualization, Writing – review & editing

  Affiliations Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany, Staburo GmbH, Munich, Germany

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• Raphael Rehms,

  Roles Conceptualization, Writing – review & editing

  Affiliations Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany, Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany, Munich Center for Machine Learning (MCML), Munich, German

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• Ulrich Mansmann

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany

  https://orcid.org/0000-0002-9955-8906

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