Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays

Andrea Salinas; Christa Burgos; Aaron Rodríguez-Ramos; Alberto Burgos-Edwards; Nelson Alvarenga; Pablo H. Sotelo; Patricia Langjahr

doi:10.1371/journal.pone.0337712

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Open Access

Peer-reviewed

Research Article

Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays

Andrea Salinas ,

Contributed equally to this work with: Andrea Salinas, Christa Burgos

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Biotechnology, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Paraguay
⨯
Christa Burgos ,

Contributed equally to this work with: Andrea Salinas, Christa Burgos

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Biotechnology, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Paraguay
⨯
Aaron Rodríguez-Ramos,

Roles Investigation, Writing – review & editing

Affiliation Department of Biotechnology, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Paraguay
⨯
Alberto Burgos-Edwards,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Phytochemistry, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Paraguay
⨯
Nelson Alvarenga,

Roles Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Phytochemistry, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Paraguay
⨯
Pablo H. Sotelo,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Biotechnology, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Paraguay
⨯
Patricia Langjahr

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: plangjahr@qui.una.py

Affiliation Department of Biotechnology, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Paraguay

https://orcid.org/0000-0001-9793-3373

⨯

Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays

Andrea Salinas,
Christa Burgos,
Aaron Rodríguez-Ramos,
Alberto Burgos-Edwards,
Nelson Alvarenga,
Pablo H. Sotelo,
Patricia Langjahr

Published: November 26, 2025
https://doi.org/10.1371/journal.pone.0337712

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