Non-muscle myosin IIC predominantly expressed in the slow-twitch skeletal muscles impedes age-related muscle weakness

Hiroki Hamaguchi; Shino Hiraoka; Kun Tang; Haonan Zhu; Yoshitaka Mita; Yasuro Furuichi; Nobuharu L. Fujii; Yasuko Manabe

doi:10.1371/journal.pone.0337708

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Open Access

Peer-reviewed

Research Article

Non-muscle myosin IIC predominantly expressed in the slow-twitch skeletal muscles impedes age-related muscle weakness

Hiroki Hamaguchi,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft

Affiliation Takasaki Institute for Advanced Quantum Science, National Institutes for Quantum Science and Technology, Watanukimachi, Takasaki-shi, Gunma, Japan
⨯
Shino Hiraoka,

Roles Conceptualization, Formal analysis, Investigation

Affiliation Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Minami-Osawa, Hachioji-shi, Tokyo, Japan
⨯
Kun Tang,

Roles Conceptualization, Formal analysis, Investigation

Affiliation Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Minami-Osawa, Hachioji-shi, Tokyo, Japan
⨯
Haonan Zhu,

Roles Conceptualization, Formal analysis, Investigation

Affiliation Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Minami-Osawa, Hachioji-shi, Tokyo, Japan
⨯
Yoshitaka Mita,

Roles Conceptualization, Formal analysis, Investigation

Affiliation Department of Immunology, Graduate School of Medicine, Juntendo University, Hongo, Bunkyo-ku, Tokyo, Japan
⨯
Yasuro Furuichi,

Roles Conceptualization, Funding acquisition

Affiliation Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Minami-Osawa, Hachioji-shi, Tokyo, Japan
⨯
Nobuharu L. Fujii,

Roles Conceptualization, Funding acquisition

Affiliation Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Minami-Osawa, Hachioji-shi, Tokyo, Japan
⨯
Yasuko Manabe

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft

* E-mail: ymanabe@tmu.ac.jp

Affiliation Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Minami-Osawa, Hachioji-shi, Tokyo, Japan
⨯

Non-muscle myosin IIC predominantly expressed in the slow-twitch skeletal muscles impedes age-related muscle weakness

Hiroki Hamaguchi,
Shino Hiraoka,
Kun Tang,
Haonan Zhu,
Yoshitaka Mita,
Yasuro Furuichi,
Nobuharu L. Fujii,
Yasuko Manabe

Published: December 4, 2025
https://doi.org/10.1371/journal.pone.0337708

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Skeletal muscles
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Slow-twitch muscle fibers
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Myoblasts
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Musculoskeletal mechanics
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Mitochondria
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Soleus muscles
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Fast-twitch muscle fibers
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Muscle contraction
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