Quantitative proteomic analysis reveals key proteins involved in radiation-induced brain injury

Jing Liu; Junshuang Wang; Shuang Lv; Hengjiao Wang; Defu Yang; Ying Zhang; Ying Li; Huiling Qu; Ying Xu; Ying Yan

doi:10.1371/journal.pone.0337608

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Open Access

Peer-reviewed

Research Article

Quantitative proteomic analysis reveals key proteins involved in radiation-induced brain injury

Jing Liu ,

Contributed equally to this work with: Jing Liu, Junshuang Wang

Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, China, Graduate School of Dalian Medical University, Dalian, China
⨯
Junshuang Wang ,

Contributed equally to this work with: Jing Liu, Junshuang Wang

Roles Data curation, Methodology, Validation

Affiliation Department of Abdominal Radiation Oncology Ward I, Cancer Hospital of Dalian University of Technology, Shenyang, China
⨯
Shuang Lv,

Roles Data curation

Affiliation Shandong Province Heze Municipal Hospital, Heze, China
⨯
Hengjiao Wang,

Roles Data curation

Affiliation Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, China
⨯
Defu Yang,

Roles Data curation

Affiliation Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, China
⨯
Ying Zhang,

Roles Data curation

Affiliation Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, China
⨯
Ying Li,

Roles Data curation

Affiliation Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, China
⨯
Huiling Qu,

Roles Data curation, Funding acquisition

Affiliation Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China
⨯
Ying Xu ,

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: 514705167@qq.com (YX); yanyingdoctor@sina.com (YY)

Affiliation Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, China

https://orcid.org/0000-0002-5523-4168

⨯
Ying Yan

Roles Project administration, Supervision, Writing – review & editing

* E-mail: 514705167@qq.com (YX); yanyingdoctor@sina.com (YY)

Affiliation Department of Radiation Oncology, General Hospital of Northern Theater Command, Shenyang, China
⨯

Quantitative proteomic analysis reveals key proteins involved in radiation-induced brain injury

Jing Liu,
Junshuang Wang,
Shuang Lv,
Hengjiao Wang,
Defu Yang,
Ying Zhang,
Ying Li,
Huiling Qu,
Ying Xu,
Ying Yan

Published: November 25, 2025
https://doi.org/10.1371/journal.pone.0337608

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