hUMSCs-exo@Cyasterone protects the cell model of steroid-induced femur head necrosis by regulating N-glycosylation modification of CTSD-N258A

Youqiang Sun; Mengmeng Liang; Yuemeng Xing; Yifan Duan; Baogui Deng; Xiaobing Xiang

doi:10.1371/journal.pone.0337562

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Open Access

Peer-reviewed

Research Article

hUMSCs-exo@Cyasterone protects the cell model of steroid-induced femur head necrosis by regulating N-glycosylation modification of CTSD-N258A

Youqiang Sun ,

Contributed equally to this work with: Youqiang Sun, Mengmeng Liang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Sports Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

https://orcid.org/0000-0001-8935-5374

⨯
Mengmeng Liang ,

Contributed equally to this work with: Youqiang Sun, Mengmeng Liang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliation Department of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Yuemeng Xing,

Roles Investigation, Methodology, Writing – original draft

Affiliation The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Yifan Duan,

Roles Investigation, Methodology, Writing – original draft

Affiliation The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Baogui Deng,

Roles Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliations Department of Sports Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Xiaobing Xiang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: smcknot@163.com

Affiliations Department of Sports Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

https://orcid.org/0000-0002-4659-6335

⨯

hUMSCs-exo@Cyasterone protects the cell model of steroid-induced femur head necrosis by regulating N-glycosylation modification of CTSD-N258A

Youqiang Sun,
Mengmeng Liang,
Yuemeng Xing,
Yifan Duan,
Baogui Deng,
Xiaobing Xiang

Published: April 3, 2026
https://doi.org/10.1371/journal.pone.0337562

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