Integrative computational, synthetic, experimental evaluation of targeted inhibitors against matrix metalloproteinase-9: Toward precision modulation of proteolytic activity

Zainab Ahmed Rashid; Dima A. Sabbah; Kamal Sweidan; Rima Hajjo; Sanaa K. Bardaweel

doi:10.1371/journal.pone.0337544

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Peer-reviewed

Research Article

Integrative computational, synthetic, experimental evaluation of targeted inhibitors against matrix metalloproteinase-9: Toward precision modulation of proteolytic activity

Zainab Ahmed Rashid,

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Amman, Jordan
⨯
Dima A. Sabbah ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: dima.sabbah@zuj.edu.jo (DAS); s.bardaweel@ju.edu.jo (SKB)

Affiliation Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan

https://orcid.org/0000-0003-1428-5097

⨯
Kamal Sweidan,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Department of Chemistry, The University of Jordan, Amman, Jordan
⨯
Rima Hajjo,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

Affiliations Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan, Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Sanaa K. Bardaweel

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: dima.sabbah@zuj.edu.jo (DAS); s.bardaweel@ju.edu.jo (SKB)

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Amman, Jordan

https://orcid.org/0000-0002-4823-0708

⨯

Integrative computational, synthetic, experimental evaluation of targeted inhibitors against matrix metalloproteinase-9: Toward precision modulation of proteolytic activity

Zainab Ahmed Rashid,
Dima A. Sabbah,
Kamal Sweidan,
Rima Hajjo,
Sanaa K. Bardaweel

Published: February 17, 2026
https://doi.org/10.1371/journal.pone.0337544

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