Second-line treatment strategies of ulcerative colitis after conventional therapy failure: A systematic review and network meta-analysis of randomized controlled trials

Yanan Xu; Wenshuo Jiang; Meizhu Jiang; Bin Zhu; Jiping Huo; Mingfen Wu; Li Yang

doi:10.1371/journal.pone.0337222

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Open Access

Peer-reviewed

Research Article

Second-line treatment strategies of ulcerative colitis after conventional therapy failure: A systematic review and network meta-analysis of randomized controlled trials

Yanan Xu ,

Contributed equally to this work with: Yanan Xu, Wenshuo Jiang

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliations Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China, School of Pharmaceutical Sciences, Capital Medical University, Beijing, P.R. China
⨯
Wenshuo Jiang ,

Contributed equally to this work with: Yanan Xu, Wenshuo Jiang

Roles Data curation, Formal analysis, Writing – review & editing

Affiliations Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China, School of Pharmaceutical Sciences, Capital Medical University, Beijing, P.R. China

https://orcid.org/0009-0002-0372-7785

⨯
Meizhu Jiang,

Roles Formal analysis, Writing – review & editing

Affiliations Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China, School of Pharmaceutical Sciences, Capital Medical University, Beijing, P.R. China
⨯
Bin Zhu,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China
⨯
Jiping Huo,

Roles Investigation, Validation, Writing – review & editing

Affiliation Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China
⨯
Mingfen Wu,

Roles Methodology, Validation, Writing – review & editing

Affiliation Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China
⨯
Li Yang

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: 0530yangli@163.com

Affiliation Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China
⨯

Second-line treatment strategies of ulcerative colitis after conventional therapy failure: A systematic review and network meta-analysis of randomized controlled trials

Yanan Xu,
Wenshuo Jiang,
Meizhu Jiang,
Bin Zhu,
Jiping Huo,
Mingfen Wu,
Li Yang

Published: December 1, 2025
https://doi.org/10.1371/journal.pone.0337222

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Ulcerative colitis
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Colectomy
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