Single-cell RNA sequencing reveals the role of immunoinflammatory cells in the progression of renal tubulointerstitial fibrosis

Xiaoqin Ye; Youcai Xu; Shanshan Wu; Yu Peng; Liwen Gao; Xi Huang; Lingfei Lu; Jiandong Lu; Xinhui Liu

doi:10.1371/journal.pone.0337092

Loading metrics

Open Access

Peer-reviewed

Research Article

Single-cell RNA sequencing reveals the role of immunoinflammatory cells in the progression of renal tubulointerstitial fibrosis

Xiaoqin Ye ,

Contributed equally to this work with: Xiaoqin Ye, Youcai Xu, Shanshan Wu

Roles Formal analysis, Writing – original draft

Affiliations Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Youcai Xu ,

Contributed equally to this work with: Xiaoqin Ye, Youcai Xu, Shanshan Wu

Roles Formal analysis, Methodology, Visualization

Affiliations Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Shanshan Wu ,

Contributed equally to this work with: Xiaoqin Ye, Youcai Xu, Shanshan Wu

Roles Data curation, Formal analysis, Methodology

Affiliations Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Yu Peng,

Roles Data curation, Formal analysis, Software

Affiliations Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Liwen Gao,

Roles Methodology, Software, Validation

Affiliations Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, China
⨯
Xi Huang,

Roles Data curation, Methodology, Validation

Affiliation Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Lingfei Lu,

Roles Data curation, Formal analysis

Affiliation Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Jiandong Lu ,

Roles Funding acquisition, Supervision

* E-mail: lujiandong@yeah.net (JL); liuxinhui0317@163.com (XL)

Affiliation Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Xinhui Liu

Roles Funding acquisition, Writing – review & editing

* E-mail: lujiandong@yeah.net (JL); liuxinhui0317@163.com (XL)

Affiliation Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China

https://orcid.org/0000-0002-0706-7836

⨯

Single-cell RNA sequencing reveals the role of immunoinflammatory cells in the progression of renal tubulointerstitial fibrosis

Xiaoqin Ye,
Youcai Xu,
Shanshan Wu,
Yu Peng,
Liwen Gao,
Xi Huang,
Lingfei Lu,
Jiandong Lu,
Xinhui Liu

Published: November 21, 2025
https://doi.org/10.1371/journal.pone.0337092

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Neutrophils
Is the Subject Area "Neutrophils" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.