The mediating role of blood metabolites in the association between myocardial infarction and cancer risk: An observational and mendelian randomization analysis

Jia Zhu; Xiaojun Xia; Haodong Jiang; Congying Wang; Yunpeng Jin

doi:10.1371/journal.pone.0336980

Loading metrics

Open Access

Peer-reviewed

Research Article

The mediating role of blood metabolites in the association between myocardial infarction and cancer risk: An observational and mendelian randomization analysis

Jia Zhu,

Roles Conceptualization, Data curation, Methodology, Writing – original draft

Affiliation Department of Cardiology, Center for Cardiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China
⨯
Xiaojun Xia,

Roles Methodology, Visualization

Affiliation Department of Cardiology, Center for Cardiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China
⨯
Haodong Jiang,

Roles Visualization, Writing – review & editing

Affiliation Department of Cardiology, Center for Cardiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China
⨯
Congying Wang,

Roles Writing – review & editing

Affiliation Department of Cardiology, Center for Cardiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China
⨯
Yunpeng Jin

Roles Writing – review & editing

* E-mail: 8013013@zju.edu.cn

Affiliation Department of Cardiology, Center for Cardiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China

https://orcid.org/0000-0003-4242-7072

⨯

The mediating role of blood metabolites in the association between myocardial infarction and cancer risk: An observational and mendelian randomization analysis

Jia Zhu,
Xiaojun Xia,
Haodong Jiang,
Congying Wang,
Yunpeng Jin

Published: November 14, 2025
https://doi.org/10.1371/journal.pone.0336980

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Myocardial infarction
Is the Subject Area "Myocardial infarction" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Head and neck cancers
Is the Subject Area "Head and neck cancers" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Colorectal cancer
Is the Subject Area "Colorectal cancer" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
Renal cancer
Is the Subject Area "Renal cancer" applicable to this article?

Thanks for your feedback.
Cancer risk factors
Is the Subject Area "Cancer risk factors" applicable to this article?

Thanks for your feedback.