Surface anticoagulation of mechanical heart valves using electrically induced biomimetic glycocalyx: An in-vitro study to assess hemocompatibility and optimal voltage

Lokeswara Rao Sajja; Aditya Koppula; Thomas Mathew; Anugya Bhatt

doi:10.1371/journal.pone.0336760

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Peer-reviewed

Research Article

Surface anticoagulation of mechanical heart valves using electrically induced biomimetic glycocalyx: An in-vitro study to assess hemocompatibility and optimal voltage

Lokeswara Rao Sajja ,

Contributed equally to this work with: Lokeswara Rao Sajja, Aditya Koppula, Thomas Mathew, Anugya Bhatt

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sajjalr@yahoo.com (LKR); aditya2171985@gmail.com (AK)

Affiliations Department of Cardiothoracic Surgery, STAR Hospitals, Hyderabad, Telangana, India, Department of Clinical Research, Sajja Heart Foundation, Hyderabad, Telangana, India

https://orcid.org/0000-0003-0842-7458

⨯
Aditya Koppula ,

Contributed equally to this work with: Lokeswara Rao Sajja, Aditya Koppula, Thomas Mathew, Anugya Bhatt

Roles Data curation, Formal analysis, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: sajjalr@yahoo.com (LKR); aditya2171985@gmail.com (AK)

Affiliations Department of Clinical Research, Sajja Heart Foundation, Hyderabad, Telangana, India, Department of Physiology, ESIC Medical College and Hospital, Hyderabad, Telangana, India

https://orcid.org/0000-0002-0978-4142

⨯
Thomas Mathew ,

Contributed equally to this work with: Lokeswara Rao Sajja, Aditya Koppula, Thomas Mathew, Anugya Bhatt

Roles Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Department of Cardiothoracic Surgery, STAR Hospitals, Hyderabad, Telangana, India, Department of Clinical Research, Sajja Heart Foundation, Hyderabad, Telangana, India
⨯
Anugya Bhatt

Contributed equally to this work with: Lokeswara Rao Sajja, Aditya Koppula, Thomas Mathew, Anugya Bhatt

Roles Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Thrombosis research, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvanthapuram, Kerala, India
⨯

Surface anticoagulation of mechanical heart valves using electrically induced biomimetic glycocalyx: An in-vitro study to assess hemocompatibility and optimal voltage

Lokeswara Rao Sajja,
Aditya Koppula,
Thomas Mathew,
Anugya Bhatt

Published: May 6, 2026
https://doi.org/10.1371/journal.pone.0336760

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