Safety of penicillamine and trientine in the treatment of Wilson’s disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database

Wenlong Qian; Kou Xu; Shuo Li; Zhuo Zhang; Xiaoxiao Hou; Bingjie Min; Jia Ling; Xinyu Zhu; Hui Zhou; Wenjuan Xu; Wenming Yang; Shijian Cao; Yonghua Chen

doi:10.1371/journal.pone.0336721

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Open Access

Peer-reviewed

Research Article

Safety of penicillamine and trientine in the treatment of Wilson’s disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database

Wenlong Qian ,

Contributed equally to this work with: Wenlong Qian, Kou Xu, Shuo Li

Roles Formal analysis, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Kou Xu ,

Contributed equally to this work with: Wenlong Qian, Kou Xu, Shuo Li

Roles Formal analysis, Visualization, Writing – original draft

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Shuo Li ,

Contributed equally to this work with: Wenlong Qian, Kou Xu, Shuo Li

Roles Formal analysis, Methodology, Writing – original draft

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Zhuo Zhang,

Roles Data curation, Methodology, Software

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Xiaoxiao Hou,

Roles Data curation, Software

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Bingjie Min,

Roles Data curation, Software

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Jia Ling,

Roles Data curation, Software

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Xinyu Zhu,

Roles Data curation, Software

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Hui Zhou,

Roles Data curation, Software

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Wenjuan Xu,

Roles Data curation, Software

Affiliation Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China
⨯
Wenming Yang,

Roles Funding acquisition, Project administration, Resources, Supervision

Affiliations Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China, Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine, Institute of Health and Medicine Hefei Comprehensive National Science Center, Hefei, Anhui, China, Key Laboratory of Xin’An Medicine, Ministry of Education, Anhui, China
⨯
Shijian Cao,

Roles Funding acquisition, Project administration, Supervision

Affiliations Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China, Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine, Institute of Health and Medicine Hefei Comprehensive National Science Center, Hefei, Anhui, China, Key Laboratory of Xin’An Medicine, Ministry of Education, Anhui, China
⨯
Yonghua Chen

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: Yonghuachen2022@163.com

Affiliations Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China, Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine, Institute of Health and Medicine Hefei Comprehensive National Science Center, Hefei, Anhui, China, Key Laboratory of Xin’An Medicine, Ministry of Education, Anhui, China

https://orcid.org/0009-0004-2004-4358

⨯

Safety of penicillamine and trientine in the treatment of Wilson’s disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database

Wenlong Qian,
Kou Xu,
Shuo Li,
Zhuo Zhang,
Xiaoxiao Hou,
Bingjie Min,
Jia Ling,
Xinyu Zhu,
Hui Zhou,
Wenjuan Xu

Published: November 12, 2025
https://doi.org/10.1371/journal.pone.0336721

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