Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology

• Claire Verkuyl ,

  Contributed equally to this work with: Claire Verkuyl, Ari Belotserkovsky

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Ari Belotserkovsky ,

  Contributed equally to this work with: Claire Verkuyl, Ari Belotserkovsky

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Thomas Zerbes,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Declan Williams,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Medha R. Krishnan,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Sabrina Zhu,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Sophie Grunnesjӧ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Shehab Eid,

  Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Cunjie Zhang,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Supervision, Writing – review & editing

  Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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• Wenda Zhao,

  Roles Data curation, Methodology, Software, Supervision, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Leo Xu,

  Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Eleanore Lin,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0009-0002-5406-3560

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• Teaghan O’Shea,

  Roles Data curation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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• Benjamin Draper,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization, Writing – review & editing

  Affiliation Megadalton Solutions, Inc., and Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America

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• Andreas Jungman,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliations German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany, Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany

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• Patrick Most,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany, Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany

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•  [ ... ],
• Gerold Schmitt-Ulms

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Visualization, Writing – original draft

  * E-mail: g.schmittulms@utoronto.ca

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0001-6962-0919

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