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Open Access

Peer-reviewed

Research Article

Network pharmacology and experiments verify the effect of triptolide on extraocular muscle fibrosis

Minmin Jiang,

Roles Conceptualization, Writing – original draft

Affiliation Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Ping Wang,

Roles Writing – review & editing

Affiliation Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Dandan Yu,

Roles Writing – review & editing

Affiliation Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Panpan Guo,

Roles Project administration

Affiliation Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Zhiyu Qu,

Roles Writing – review & editing

Affiliation Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Jingxiao Zhao,

Roles Conceptualization

Affiliation Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Shuxun Yan

Roles Funding acquisition, Supervision

* E-mail: yanshuxun982001@126.com

Affiliation Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China

https://orcid.org/0000-0003-0910-6314

⨯

Network pharmacology and experiments verify the effect of triptolide on extraocular muscle fibrosis

Minmin Jiang,
Ping Wang,
Dandan Yu,
Panpan Guo,
Zhiyu Qu,
Jingxiao Zhao,
Shuxun Yan

x

Published: November 10, 2025
https://doi.org/10.1371/journal.pone.0336487

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Fibrosis
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Gene ontologies
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Muscle proteins
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Molecular docking
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VEGF signaling
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Signal inhibition
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