Analgesic effectiveness of wound infiltration with bupivacaine versus a mixture of bupivacaine and tramadol for postoperative pain management among parturients undergoing elective cesarean section under spinal anesthesia: A randomized controlled trial

Mesay Milkias; Semagn Mekonnen; Hailemariam Getachew; Hailemariam Mulugeta; Siraj Ahmed; Melkamu Kebede; Belete Destaw; Medhanit Melese; Zemedu Aweke

doi:10.1371/journal.pone.0336372

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Open Access

Peer-reviewed

Research Article

Analgesic effectiveness of wound infiltration with bupivacaine versus a mixture of bupivacaine and tramadol for postoperative pain management among parturients undergoing elective cesarean section under spinal anesthesia: A randomized controlled trial

Mesay Milkias ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Visualization, Writing – review & editing

* E-mail: milikiasssi@gmail.com

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia

https://orcid.org/0000-0002-0554-5400

⨯
Semagn Mekonnen,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯
Hailemariam Getachew,

Roles Conceptualization, Data curation, Formal analysis, Supervision, Visualization

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯
Hailemariam Mulugeta,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯
Siraj Ahmed,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯
Melkamu Kebede,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯
Belete Destaw,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Software

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯
Medhanit Melese,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯
Zemedu Aweke

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Anesthesia, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia
⨯

Analgesic effectiveness of wound infiltration with bupivacaine versus a mixture of bupivacaine and tramadol for postoperative pain management among parturients undergoing elective cesarean section under spinal anesthesia: A randomized controlled trial

Mesay Milkias,
Semagn Mekonnen,
Hailemariam Getachew,
Hailemariam Mulugeta,
Siraj Ahmed,
Melkamu Kebede,
Belete Destaw,
Medhanit Melese,
Zemedu Aweke

Published: November 12, 2025
https://doi.org/10.1371/journal.pone.0336372

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