Integrative machine learning and multi-omics framework identifies shared biomarkers for rheumatoid arthritis and ulcerative colitis

Meili Liu; Jun Ge; Lei Guo; Zhengzheng Wu; Zimo Cheng; Zenggen Liu; Yi Liu

doi:10.1371/journal.pone.0336243

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Open Access

Peer-reviewed

Research Article

Integrative machine learning and multi-omics framework identifies shared biomarkers for rheumatoid arthritis and ulcerative colitis

Meili Liu ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

¶☯ These authors contributed equally to this work and share first authorship.

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China

https://orcid.org/0009-0005-8817-2775

⨯
Jun Ge ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – review & editing

¶☯ These authors contributed equally to this work and share first authorship.

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China
⨯
Lei Guo,

Roles Methodology, Project administration, Supervision

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China
⨯
Zhengzheng Wu,

Roles Project administration

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China
⨯
Zimo Cheng,

Roles Project administration, Software

Affiliation Wuhan Britain-China School, Wuhan, China
⨯
Zenggen Liu ,

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: 3370@hbucm.edu.cn (ZL); 23218843@qq.com (YL)

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China
⨯
Yi Liu

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: 3370@hbucm.edu.cn (ZL); 23218843@qq.com (YL)

Affiliations Hubei Provincial Key Laboratory for Chinese Medicine Resources and Chinese Medicine Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China, Hubei Shizhen Laboratory, Wuhan, China
⨯

Integrative machine learning and multi-omics framework identifies shared biomarkers for rheumatoid arthritis and ulcerative colitis

Meili Liu,
Jun Ge,
Lei Guo,
Zhengzheng Wu,
Zimo Cheng,
Zenggen Liu,
Yi Liu

Published: November 10, 2025
https://doi.org/10.1371/journal.pone.0336243

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