Synergistic enhancement of AAV gene delivery in 2D cells and 3D organoids using polybrene and hydroxychloroquine

• Hyeon-Jin Na ,

  Contributed equally to this work with: Hyeon-Jin Na, Yongbo Shin, Seung-Hyun Kim

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliations Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Department of Advanced Bioconvergence, Korea University of Science and Technology, Daejeon, Republic of Korea

  https://orcid.org/0000-0002-8361-2162

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• Yongbo Shin ,

  Contributed equally to this work with: Hyeon-Jin Na, Yongbo Shin, Seung-Hyun Kim

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliations Department of Advanced Bioconvergence, Korea University of Science and Technology, Daejeon, Republic of Korea, Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

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• Seung-Hyun Kim ,

  Contributed equally to this work with: Hyeon-Jin Na, Yongbo Shin, Seung-Hyun Kim

  Roles Methodology, Software, Visualization

  Affiliation Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

  https://orcid.org/0009-0001-5450-5245

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• Seung Pil Jang,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliation Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

  https://orcid.org/0009-0006-6444-2379

  ⨯
• Myung Jin Son,

  Roles Writing – review & editing

  Affiliations Department of Advanced Bioconvergence, Korea University of Science and Technology, Daejeon, Republic of Korea, Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

  ⨯
• Yong Min Choi,

  Roles Resources

  Affiliations Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Department of Advanced Bioconvergence, Korea University of Science and Technology, Daejeon, Republic of Korea

  https://orcid.org/0009-0002-4318-2951

  ⨯
• Hyeon Gyeol Jeon,

  Roles Investigation, Resources, Visualization

  Affiliations Department of Advanced Bioconvergence, Korea University of Science and Technology, Daejeon, Republic of Korea, Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

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• Ok-Seon Kwon ,

  Roles Funding acquisition, Project administration, Writing – review & editing

  * E-mail: kschung@kribb.re.kr (KSC); okskwon@kribb.re.kr (OSK)

  Affiliations Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Department of Advanced Bioconvergence, Korea University of Science and Technology, Daejeon, Republic of Korea

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• Kyung-Sook Chung

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: kschung@kribb.re.kr (KSC); okskwon@kribb.re.kr (OSK)

  Affiliations Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Department of Advanced Bioconvergence, Korea University of Science and Technology, Daejeon, Republic of Korea

  https://orcid.org/0000-0002-0862-0779

  ⨯