Spinal Calcrl⁺ neurons amplify mechanical itch signaling via synaptic plasticity in chronic itch model

• Huifeng Jiao ,

  Contributed equally to this work with: Huifeng Jiao, Qi Dai

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  ⨯
• Qi Dai ,

  Contributed equally to this work with: Huifeng Jiao, Qi Dai

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuro regeneration, Nantong University, Nantong, Jiangsu, China, The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brian Health, and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  ⨯
• Zhaoting Li,

  Roles Investigation, Validation, Writing – review & editing

  Affiliations Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuro regeneration, Nantong University, Nantong, Jiangsu, China, The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brian Health, and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  https://orcid.org/0009-0009-9778-7308

  ⨯
• Min Yuan,

  Roles Validation, Writing – review & editing

  Affiliation Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China

  ⨯
• Guoqun Xu,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliations School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuro regeneration, Nantong University, Nantong, Jiangsu, China

  ⨯
• Yingxin Tian,

  Roles Validation, Writing – review & editing

  Affiliations Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuro regeneration, Nantong University, Nantong, Jiangsu, China, The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brian Health, and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  ⨯
• Guangyuan Su,

  Roles Validation, Writing – review & editing

  Affiliations School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuro regeneration, Nantong University, Nantong, Jiangsu, China

  ⨯
• Yu Zhang,

  Roles Validation, Writing – review & editing

  Affiliation The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brian Health, and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  ⨯
• Chong Sun,

  Roles Validation, Writing – review & editing

  Affiliation The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brian Health, and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  ⨯
• Shunqi Wang,

  Roles Validation, Writing – review & editing

  Affiliation The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brian Health, and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  https://orcid.org/0000-0002-4918-6550

  ⨯
• Chaolin Ma ,

  Roles Validation, Writing – review & editing

  * E-mail: panhaili@ntu.edu.cn (HP); chaolinma@ncu.edu.cn (CM)

  Affiliation The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brian Health, and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  ⨯
• Haili Pan

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: panhaili@ntu.edu.cn (HP); chaolinma@ncu.edu.cn (CM)

  Affiliation Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuro regeneration, Nantong University, Nantong, Jiangsu, China

  https://orcid.org/0000-0003-3859-0758

  ⨯