Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice

• Benjamin S. Summers,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St. Vincent’s Centre for Applied Medical Research, Sydney, New South Wales, Australia, Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia

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• Luke Milham,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia, Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, New South Wales, Australia

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• Sonia Bustamante,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, New South Wales, Australia

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• Krishan Gondal,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St. Vincent’s Centre for Applied Medical Research, Sydney, New South Wales, Australia, Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia

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• Peggy Rentsch,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia, Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, New South Wales, Australia

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• Gayathri Sundaram,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Current address: Bionyeri Pty Ltd, Hornsby, Sydney, NSW, Australia

  Affiliations Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St. Vincent’s Centre for Applied Medical Research, Sydney, New South Wales, Australia, Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia

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• Michael D. Lovelace,

  Roles Formal analysis, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St. Vincent’s Centre for Applied Medical Research, Sydney, New South Wales, Australia, Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia

  https://orcid.org/0000-0003-2066-3031

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• Bryce Vissel,

  Roles Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliations Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia, Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, New South Wales, Australia

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• Bruce J. Brew

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: b.brew@unsw.edu.au

  Affiliations Applied Neurosciences Program, Peter Duncan Neurosciences Research Unit, St. Vincent’s Centre for Applied Medical Research, Sydney, New South Wales, Australia, Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia, Departments of Neurology and Immunology, St. Vincent’s Hospital, Sydney, New South Wales, Australia, University of Notre Dame, Darlinghurst, Sydney, New South Wales, Australia

  https://orcid.org/0000-0003-0622-1392

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