Benchmarking diffusion models against state-of-the-art architectures for OCT fluid biomarker segmentation

Katherine Du; Utkarsh Doshi; Benjamin DiCenzo; Jessica Jiang; Ethan Wu; Adarsh Gadari; Sharat Chandra Vupparaboina; Elham Sadeghi; Sandeep Chandra Bollepalli; José-Alain Sahel; Jay Chhablani; Kiran Kumar Vupparaboina

doi:10.1371/journal.pone.0335615

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Open Access

Peer-reviewed

Research Article

Benchmarking diffusion models against state-of-the-art architectures for OCT fluid biomarker segmentation

Katherine Du,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Utkarsh Doshi,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Benjamin DiCenzo,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Jessica Jiang,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Ethan Wu,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Adarsh Gadari,

Roles Software, Validation

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Sharat Chandra Vupparaboina,

Roles Data curation, Resources, Software

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Elham Sadeghi,

Roles Methodology, Validation

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Sandeep Chandra Bollepalli,

Roles Conceptualization, Methodology, Supervision, Validation

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
José-Alain Sahel,

Roles Funding acquisition, Project administration, Resources, Software

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Jay Chhablani,

Roles Funding acquisition, Project administration, Resources, Software, Supervision, Validation

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Kiran Kumar Vupparaboina

Roles Conceptualization, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

* E-mail: kiran1559@gmail.com, kkv@pitt.edu

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0003-0024-8404

⨯

Benchmarking diffusion models against state-of-the-art architectures for OCT fluid biomarker segmentation

Katherine Du,
Utkarsh Doshi,
Benjamin DiCenzo,
Jessica Jiang,
Ethan Wu,
Adarsh Gadari,
Sharat Chandra Vupparaboina,
Elham Sadeghi,
Sandeep Chandra Bollepalli,
José-Alain Sahel

Published: October 29, 2025
https://doi.org/10.1371/journal.pone.0335615

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