PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence

Ya Xiao; Mao Chen; Lingyun Li; Liying Chen; Xiaoyu Tian; Xiaoyu Huang; Fangyi Zhu; Bingshu Li; Li Hong

doi:10.1371/journal.pone.0335501

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Open Access

Peer-reviewed

Research Article

PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence

Ya Xiao,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
⨯
Mao Chen,

Roles Project administration, Software

Affiliation Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
⨯
Lingyun Li,

Roles Validation, Visualization

Affiliation Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
⨯
Liying Chen,

Roles Investigation, Methodology

Affiliation Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
⨯
Xiaoyu Tian,

Roles Data curation, Formal analysis

Affiliation Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
⨯
Xiaoyu Huang,

Roles Methodology, Software

Affiliation Guangdong Provincial People’s Hospital, Guangzhou, China
⨯
Fangyi Zhu,

Roles Data curation, Software

Affiliation Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
⨯
Bingshu Li ,

Roles Conceptualization, Investigation, Methodology, Project administration

* E-mail: libingshu2005@126.com (BL); dr_hongli@whu.edu.cn (LH)

Affiliation Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China
⨯
Li Hong

Roles Funding acquisition, Project administration, Supervision

* E-mail: libingshu2005@126.com (BL); dr_hongli@whu.edu.cn (LH)

Affiliations Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China, Pelvic Floor Research Centre of Hubei Province, Renmin Hospital of Wuhan University, Wuhan, China

https://orcid.org/0000-0002-3841-5557

⨯

PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence

Ya Xiao,
Mao Chen,
Lingyun Li,
Liying Chen,
Xiaoyu Tian,
Xiaoyu Huang,
Fangyi Zhu,
Bingshu Li,
Li Hong

Published: November 12, 2025
https://doi.org/10.1371/journal.pone.0335501

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Hypoxia
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Medical hypoxia
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Mouse models
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Fibroblasts
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