Impact of Metformin therapy on miR-9, miR-223, and miR-132 and inflammasome-related gen expression in obese and non-obes PCOS patients: A comparative study with healthy controls

Seyed Alireza Mirjalili; Seyed Mehdi Kalantar; Fateme Montazeri; Reyhaneh Azizi; Elham Hosseini; Fateme Zare; Samira Asgharzade; Korosh Ashrafi Dehkordi

doi:10.1371/journal.pone.0335280

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Open Access

Peer-reviewed

Research Article

Impact of Metformin therapy on miR-9, miR-223, and miR-132 and inflammasome-related gen expression in obese and non-obes PCOS patients: A comparative study with healthy controls

Seyed Alireza Mirjalili,

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
⨯
Seyed Mehdi Kalantar,

Roles Supervision, Writing – review & editing

Affiliation Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⨯
Fateme Montazeri,

Roles Data curation, Formal analysis

Affiliation Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⨯
Reyhaneh Azizi,

Roles Data curation

Affiliation Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⨯
Elham Hosseini,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization

Affiliation Department of Obstetrics and Gynecology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
⨯
Fateme Zare,

Roles Validation, Visualization, Writing – review & editing

Affiliation Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⨯
Samira Asgharzade ,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – review & editing

* E-mail: ashrafi.k@skums.ac.ir (KAD); Asgharzade2336@gmail.com (SA)

Affiliation Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
⨯
Korosh Ashrafi Dehkordi

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Validation, Writing – review & editing

* E-mail: ashrafi.k@skums.ac.ir (KAD); Asgharzade2336@gmail.com (SA)

Affiliation Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

https://orcid.org/0000-0001-7105-731X

⨯

Impact of Metformin therapy on miR-9, miR-223, and miR-132 and inflammasome-related gen expression in obese and non-obes PCOS patients: A comparative study with healthy controls

Seyed Alireza Mirjalili,
Seyed Mehdi Kalantar,
Fateme Montazeri,
Reyhaneh Azizi,
Elham Hosseini,
Fateme Zare,
Samira Asgharzade,
Korosh Ashrafi Dehkordi

Published: December 18, 2025
https://doi.org/10.1371/journal.pone.0335280

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Obesity
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Polycystic ovary syndrome
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Inflammation
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MicroRNAs
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Inflammasomes
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Body mass index
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Insulin resistance
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Gene expression
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