Biological age threshold is associated with symptomatic knee osteoarthritis risk in chinese adults: Insights from machine learning analysis of a national cohort

Fanyu Fu; Li Dong; Jiwei Lian; Chang Liu; Tingting Pang; Yunli Wang; Peng Liu; Yufeng Wang

doi:10.1371/journal.pone.0335250

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Open Access

Peer-reviewed

Research Article

Biological age threshold is associated with symptomatic knee osteoarthritis risk in chinese adults: Insights from machine learning analysis of a national cohort

Fanyu Fu ,

Contributed equally to this work with: Fanyu Fu, Li Dong

Roles Writing – original draft

Affiliation College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin Province, China
⨯
Li Dong ,

Contributed equally to this work with: Fanyu Fu, Li Dong

Roles Writing – review & editing

Affiliation College of Rehabilitation Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, China
⨯
Jiwei Lian,

Roles Resources, Software

Affiliation Department of Tuina, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Chang Liu,

Roles Investigation, Visualization

Affiliation Department of Tuina, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
⨯
Tingting Pang,

Roles Visualization

Affiliation College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin Province, China
⨯
Yunli Wang,

Roles Formal analysis, Validation

Affiliation College of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin Province, China
⨯
Peng Liu ,

Roles Data curation, Funding acquisition, Project administration

* E-mail: 515900837@qq.com (PL); wangchn@126.com (YW)

Affiliation Department of Tuina, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China
⨯
Yufeng Wang

Roles Data curation, Funding acquisition, Project administration

* E-mail: 515900837@qq.com (PL); wangchn@126.com (YW)

Affiliation Changchun University of Chinese Medicine, Changchun, Jilin Province, China

https://orcid.org/0000-0001-6233-045X

⨯

Biological age threshold is associated with symptomatic knee osteoarthritis risk in chinese adults: Insights from machine learning analysis of a national cohort

Fanyu Fu,
Li Dong,
Jiwei Lian,
Chang Liu,
Tingting Pang,
Yunli Wang,
Peng Liu,
Yufeng Wang

Published: December 17, 2025
https://doi.org/10.1371/journal.pone.0335250

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