Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway

Yi You; Yaping Shen; Yan Yang; Xiaoyang Wei; Yuheng Zhou; Foxing Tan; Longcheng Deng; Haolin Du; Sen Wang; Cheng Wang; Yan Huang

doi:10.1371/journal.pone.0335225

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Open Access

Peer-reviewed

Research Article

Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway

Yi You ,

Contributed equally to this work with: Yi You, Yaping Shen

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yaping Shen ,

Contributed equally to this work with: Yi You, Yaping Shen

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yan Yang ,

Roles Formal analysis, Writing – review & editing

¶‡ These authors also contributed equally to this work.

Affiliation Nanjing University of Chinese Medicine, Nanjing, China
⨯
Xiaoyang Wei ,

Roles Resources

¶‡ These authors also contributed equally to this work.

Affiliation Nanjing Tech University, Nanjing, China
⨯
Yuheng Zhou ,

Roles Formal analysis

¶‡ These authors also contributed equally to this work.

Affiliation Nanjing University of Chinese Medicine, Nanjing, China
⨯
Foxing Tan ,

Roles Data curation

¶‡ These authors also contributed equally to this work.

Affiliation Nanjing University of Chinese Medicine, Nanjing, China
⨯
Longcheng Deng ,

Roles Formal analysis

¶‡ These authors also contributed equally to this work.

Affiliation Nanjing University of Chinese Medicine, Nanjing, China
⨯
Haolin Du ,

Roles Formal analysis

¶‡ These authors also contributed equally to this work.

Affiliation Nanjing University of Chinese Medicine, Nanjing, China
⨯
Sen Wang,

Roles Resources, Supervision

Affiliation Nanjing Tech University, Nanjing, China
⨯
Cheng Wang,

Roles Methodology, Supervision, Validation

Affiliation Department of Ultrasound, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yan Huang

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization

* E-mail: jacob666@163.com

Affiliation Department of Ultrasound, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China

https://orcid.org/0000-0001-6857-9168

⨯

Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway

Yi You,
Yaping Shen,
Yan Yang,
Xiaoyang Wei,
Yuheng Zhou,
Foxing Tan,
Longcheng Deng,
Haolin Du,
Sen Wang,
Cheng Wang

Published: October 22, 2025
https://doi.org/10.1371/journal.pone.0335225

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Fibrosis
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Gastrointestinal tract
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Gene expression
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