Impact of hydatid cyst laminated layer antigens on cell death rate, apoptosis induction, and key genes in the cell proliferation pathway: Insights from A549 cell line studies

ElaheSadat Hosseini; Masoumeh Tavakoli-Yaraki; Ahmad Reza Meamar; Zeynab Ajam; Maryam Alipour; Ruchika Bagga; Elham Razmjou; Raheleh Rafiei-Sefiddashti

doi:10.1371/journal.pone.0335188

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Open Access

Peer-reviewed

Research Article

Impact of hydatid cyst laminated layer antigens on cell death rate, apoptosis induction, and key genes in the cell proliferation pathway: Insights from A549 cell line studies

ElaheSadat Hosseini,

Roles Data curation, Investigation, Writing – original draft

Affiliation Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Masoumeh Tavakoli-Yaraki,

Roles Data curation, Methodology, Validation, Writing – review & editing

Affiliation Department of Clinical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Ahmad Reza Meamar,

Roles Writing – review & editing

Affiliation Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Zeynab Ajam,

Roles Data curation, Formal analysis

Affiliation Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Maryam Alipour,

Roles Data curation, Formal analysis

Affiliation Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Ruchika Bagga,

Roles Writing – review & editing

Affiliation Fortis Memorial Research Institute, Gurgaon, Haryana, India

https://orcid.org/0000-0003-1279-1738

⨯
Elham Razmjou ,

Roles Supervision, Validation, Writing – review & editing

* E-mail: razmjou.e@iums.ac.ir (ER); r.rafiei.sd@gmail.com (RR-S)

Affiliation Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

https://orcid.org/0000-0001-6370-1849

⨯
Raheleh Rafiei-Sefiddashti

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: razmjou.e@iums.ac.ir (ER); r.rafiei.sd@gmail.com (RR-S)

Affiliation Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

https://orcid.org/0000-0001-5489-823X

⨯

Impact of hydatid cyst laminated layer antigens on cell death rate, apoptosis induction, and key genes in the cell proliferation pathway: Insights from A549 cell line studies

ElaheSadat Hosseini,
Masoumeh Tavakoli-Yaraki,
Ahmad Reza Meamar,
Zeynab Ajam,
Maryam Alipour,
Ruchika Bagga,
Elham Razmjou,
Raheleh Rafiei-Sefiddashti

Published: October 24, 2025
https://doi.org/10.1371/journal.pone.0335188

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