Assessing NaV1.7 during tonic firing in pig C-nociceptors

Sabrina Soares; Martin Schmelz; Richard Carr; Kyra Sohns; Roman Rukwied

doi:10.1371/journal.pone.0335081

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Open Access

Peer-reviewed

Research Article

Assessing NaV1.7 during tonic firing in pig C-nociceptors

Sabrina Soares ,

Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Sabrina.Soares@medma.uni-heidelberg.de (SS); Roman.Rukwied@medma.uni-heidelberg.de (RR)

Affiliation Department of Experimental Pain Research, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience, University of Heidelberg, Heidelberg, Germany

https://orcid.org/0000-0003-0088-0362

⨯
Martin Schmelz,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Experimental Pain Research, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience, University of Heidelberg, Heidelberg, Germany
⨯
Richard Carr,

Roles Formal analysis

Affiliation Department of Experimental Pain Research, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience, University of Heidelberg, Heidelberg, Germany
⨯
Kyra Sohns,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Experimental Pain Research, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience, University of Heidelberg, Heidelberg, Germany
⨯
Roman Rukwied

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: Sabrina.Soares@medma.uni-heidelberg.de (SS); Roman.Rukwied@medma.uni-heidelberg.de (RR)

Affiliation Department of Experimental Pain Research, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience, University of Heidelberg, Heidelberg, Germany

https://orcid.org/0000-0003-4118-497X

⨯

Assessing NaV1.7 during tonic firing in pig C-nociceptors

Sabrina Soares,
Martin Schmelz,
Richard Carr,
Kyra Sohns,
Roman Rukwied

Published: December 3, 2025
https://doi.org/10.1371/journal.pone.0335081

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Sine waves
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Action potentials
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Nociceptors
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