The impact of dose and discontinuation timing of preoperative ACE inhibitors on survival outcomes in cardiac surgery: A MIMIC-IV database analysis

Xiu Zou; Shengyang Chen; Lingyan Hu; Lan Sha; Jianxing Zhou; Hongqiang Qiu; Xuemei Wu

doi:10.1371/journal.pone.0334889

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Open Access

Peer-reviewed

Research Article

The impact of dose and discontinuation timing of preoperative ACE inhibitors on survival outcomes in cardiac surgery: A MIMIC-IV database analysis

Xiu Zou ,

Contributed equally to this work with: Xiu Zou, Shengyang Chen

Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
⨯
Shengyang Chen ,

Contributed equally to this work with: Xiu Zou, Shengyang Chen

Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
⨯
Lingyan Hu,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

Affiliation Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
⨯
Lan Sha,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Pharmacy, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China,
⨯
Jianxing Zhou,

Roles Methodology, Validation, Writing – review & editing, Data curation, Formal analysis

Affiliations Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China
⨯
Hongqiang Qiu ,

Roles Conceptualization, Data curation, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: hongqiangqiu@fjmu.edu.cn (HQ); wuxuemei@fjmu.edu.cn (XW)

Affiliation Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
⨯
Xuemei Wu

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: hongqiangqiu@fjmu.edu.cn (HQ); wuxuemei@fjmu.edu.cn (XW)

Affiliation Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

https://orcid.org/0009-0003-0895-9849

⨯

The impact of dose and discontinuation timing of preoperative ACE inhibitors on survival outcomes in cardiac surgery: A MIMIC-IV database analysis

Xiu Zou,
Shengyang Chen,
Lingyan Hu,
Lan Sha,
Jianxing Zhou,
Hongqiang Qiu,
Xuemei Wu

Published: November 10, 2025
https://doi.org/10.1371/journal.pone.0334889

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