Dual function of mitochondrial complex III in Plasmodium falciparum

River S. Rell; Anurag Shukla; Joanne M. Morrisey; Ijeoma C. Okoye; Michael W. Mather; Akhil B. Vaidya

doi:10.1371/journal.pone.0334727

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Open Access

Peer-reviewed

Research Article

Dual function of mitochondrial complex III in Plasmodium falciparum

River S. Rell,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

Affiliation Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0009-0007-8829-9543

⨯
Anurag Shukla,

Roles Formal analysis, Methodology, Visualization, Writing – review & editing

Affiliation Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0003-4035-2978

⨯
Joanne M. Morrisey,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Ijeoma C. Okoye,

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Affiliation Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Michael W. Mather,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-1062-0137

⨯
Akhil B. Vaidya

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: av27@drexel.edu

Affiliation Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0003-1063-5571

⨯

Dual function of mitochondrial complex III in Plasmodium falciparum

River S. Rell,
Anurag Shukla,
Joanne M. Morrisey,
Ijeoma C. Okoye,
Michael W. Mather,
Akhil B. Vaidya

Published: February 20, 2026
https://doi.org/10.1371/journal.pone.0334727

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Mitochondria
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Membrane potential
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Malarial parasites
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Mitochondrial DNA
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Proguanil
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Mitochondrial membrane
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Plasmodium
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Immunoprecipitation
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