Carbonizing technology enables Sanguisorbae Radix to inhibit yeast-to-hypha differentiation and biofilm formation in Candida albicans

Xuxi Cheng; Jinyun Song; Qinglian Hu; Hongdan Wu; Bohui Song; Ruixiao Ma; Jinghan Gao; Yiwei Wang; Huangjin Tong; Wei Gu; Hongyu Zhao

doi:10.1371/journal.pone.0334659

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Open Access

Peer-reviewed

Research Article

Carbonizing technology enables Sanguisorbae Radix to inhibit yeast-to-hypha differentiation and biofilm formation in Candida albicans

Xuxi Cheng ,

Contributed equally to this work with: Xuxi Cheng, Jinyun Song, Qinglian Hu

Roles Writing – original draft

Affiliations Department of Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Jinyun Song ,

Contributed equally to this work with: Xuxi Cheng, Jinyun Song, Qinglian Hu

Roles Funding acquisition, Investigation

Affiliation Department of Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
⨯
Qinglian Hu ,

Contributed equally to this work with: Xuxi Cheng, Jinyun Song, Qinglian Hu

Roles Writing – original draft

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Hongdan Wu,

Roles Investigation

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Bohui Song,

Roles Investigation

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Ruixiao Ma,

Roles Investigation

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Jinghan Gao,

Roles Investigation

Affiliation Department of Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yiwei Wang,

Roles Writing – review & editing

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Huangjin Tong ,

Roles Funding acquisition

* E-mail: njdie001@njucm.edu.cn (HZ); guwei@njucm.edu.cn (WG); tonghj@jsatcm.com (HT)

Affiliation Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Wei Gu ,

Roles Funding acquisition, Writing – review & editing

* E-mail: njdie001@njucm.edu.cn (HZ); guwei@njucm.edu.cn (WG); tonghj@jsatcm.com (HT)

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Hongyu Zhao

Roles Funding acquisition, Writing – review & editing

* E-mail: njdie001@njucm.edu.cn (HZ); guwei@njucm.edu.cn (WG); tonghj@jsatcm.com (HT)

Affiliation Department of Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China

https://orcid.org/0009-0007-3338-939X

⨯

Carbonizing technology enables Sanguisorbae Radix to inhibit yeast-to-hypha differentiation and biofilm formation in Candida albicans

Xuxi Cheng,
Jinyun Song,
Qinglian Hu,
Hongdan Wu,
Bohui Song,
Ruixiao Ma,
Jinghan Gao,
Yiwei Wang,
Huangjin Tong,
Wei Gu

Published: October 17, 2025
https://doi.org/10.1371/journal.pone.0334659

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Biofilms
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Gene expression
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Candida albicans
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