Design, synthesis, and biological evaluation of phenylisoxazole-based histone deacetylase inhibitors

• Xiaofei Qin ,

  Roles Data curation, Funding acquisition, Validation, Writing – original draft

  * E-mail: 18537333007@163.com

  Affiliations Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Henan Province Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Xinxiang Key Laboratory for Individualized Drug Use Research for Immune Diseases, Weihui, China, Xinxiang Anti-Oesophageal Cancer Nano-targeted Drug Delivery Engineering and Technology Research Centre, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Xinxiang City Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China

  https://orcid.org/0009-0009-4156-2708

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• Meng Han,

  Roles Software, Visualization, Writing – original draft

  Affiliations Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Henan Province Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Xinxiang Key Laboratory for Individualized Drug Use Research for Immune Diseases, Weihui, China, Xinxiang Anti-Oesophageal Cancer Nano-targeted Drug Delivery Engineering and Technology Research Centre, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Xinxiang City Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China

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• Peng Hu,

  Roles Formal analysis, Investigation, Methodology, Software

  Affiliations Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Henan Province Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Xinxiang Key Laboratory for Individualized Drug Use Research for Immune Diseases, Weihui, China, Xinxiang Anti-Oesophageal Cancer Nano-targeted Drug Delivery Engineering and Technology Research Centre, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Xinxiang City Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China

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• Huadong Que,

  Roles Resources, Software, Validation, Visualization

  Affiliations Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Henan Province Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Xinxiang Key Laboratory for Individualized Drug Use Research for Immune Diseases, Weihui, China, Xinxiang Anti-Oesophageal Cancer Nano-targeted Drug Delivery Engineering and Technology Research Centre, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Xinxiang City Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China

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• Zhenlei Shao,

  Roles Methodology, Software, Validation

  Affiliations Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Henan Province Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Xinxiang Key Laboratory for Individualized Drug Use Research for Immune Diseases, Weihui, China, Xinxiang Anti-Oesophageal Cancer Nano-targeted Drug Delivery Engineering and Technology Research Centre, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Xinxiang City Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China

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• Dong Yan

  Roles Resources, Writing – review & editing

  Affiliations Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Henan Province Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Xinxiang Key Laboratory for Individualized Drug Use Research for Immune Diseases, Weihui, China, Xinxiang Anti-Oesophageal Cancer Nano-targeted Drug Delivery Engineering and Technology Research Centre, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China, Clinical Pharmacy, Xinxiang City Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China

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