EGFR-targeted affibody–polyIC polyplex kills EGFR-overexpressing cancer cells without activating the EGFR

• Anne Pettikiriarachchi ,

  Contributed equally to this work with: Anne Pettikiriarachchi, Yelena Ugolev

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Writing – review & editing

  ¶‡ These authors share first authorship for this work.

  Affiliations Personal Oncology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, Structural Biology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

  ⨯
• Yelena Ugolev ,

  Contributed equally to this work with: Anne Pettikiriarachchi, Yelena Ugolev

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship for this work.

  Affiliation Unit of Cellular Signaling, Silberman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel

  ⨯
• Richard Birkinshaw,

  Roles Formal analysis, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Structural Biology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

  ⨯
• Ahmad Wardak,

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation Structural Biology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

  ⨯
• Maree C. Faux,

  Roles Methodology, Writing – review & editing

  Affiliations Personal Oncology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, Structural Biology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

  ⨯
• Timothy E. Adams,

  Roles Methodology, Resources, Writing – original draft

  Affiliation CSIRO Manufacturing, Clayton, Victoria, Australia

  ⨯
• Salim Joubran,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Unit of Cellular Signaling, Silberman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel

  ⨯
• Alexei Shir,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Unit of Cellular Signaling, Silberman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel

  ⨯
• Nufar Edinger,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Unit of Cellular Signaling, Silberman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel

  ⨯
• Maya Zigler,

  Roles Supervision, Writing – original draft, Writing – review & editing

  Affiliation Unit of Cellular Signaling, Silberman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel

  ⨯
• Alexander Levitzki,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Unit of Cellular Signaling, Silberman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel

  ⨯
• Antony W. Burgess

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: tburgess@wehi.edu.au

  Affiliations Personal Oncology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, Structural Biology, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, Department of Surgery (RMH), University of Melbourne, Parkville, Australia

  https://orcid.org/0000-0003-3275-9209

  ⨯