A FtsZ inhibitor-acinetobactin conjugate with enhanced cellular uptake in Acinetobacter baumannii acts synergistically in combination with PBP3-targeting antibiotics

Eric J. Bryan; Zoltan Szekely; Yuxuan Wang; Huizhou Fan; Lucile Moynié; Jacques Y. Roberge; Daniel S. Pilch

doi:10.1371/journal.pone.0334409

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Peer-reviewed

Research Article

A FtsZ inhibitor-acinetobactin conjugate with enhanced cellular uptake in Acinetobacter baumannii acts synergistically in combination with PBP3-targeting antibiotics

Eric J. Bryan,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Zoltan Szekely,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Molecular Design and Synthesis, Office for Research, Rutgers University Core Services, Piscataway, New Jersey, United States of America
⨯
Yuxuan Wang,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Huizhou Fan,

Roles Conceptualization, Formal analysis, Supervision

Affiliation Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Lucile Moynié,

Roles Conceptualization, Methodology

Affiliation Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford, United Kingdom

https://orcid.org/0000-0002-4097-4331

⨯
Jacques Y. Roberge,

Roles Conceptualization, Formal analysis, Methodology, Supervision

Affiliation Department of Molecular Design and Synthesis, Office for Research, Rutgers University Core Services, Piscataway, New Jersey, United States of America
⨯
Daniel S. Pilch

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: pilchds@rwjms.rutgers.edu

Affiliation Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America

https://orcid.org/0000-0002-0113-0849

⨯

A FtsZ inhibitor-acinetobactin conjugate with enhanced cellular uptake in Acinetobacter baumannii acts synergistically in combination with PBP3-targeting antibiotics

Eric J. Bryan,
Zoltan Szekely,
Yuxuan Wang,
Huizhou Fan,
Lucile Moynié,
Jacques Y. Roberge,
Daniel S. Pilch

Published: October 14, 2025
https://doi.org/10.1371/journal.pone.0334409

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