Global temporal trends and projections of gastroesophageal reflux disease prevalence: Age-period-cohort analysis 2021

Feng Xie; Baoqin Yang; Zeng Yan; Yong Shen; Hui Qin; Li Chen; Tiantian Chen; Jigui Chen; Shaihong Zhu; Fei Xiong; Xulong Sun

doi:10.1371/journal.pone.0334396

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Open Access

Peer-reviewed

Research Article

Global temporal trends and projections of gastroesophageal reflux disease prevalence: Age-period-cohort analysis 2021

Feng Xie,

Roles Writing – original draft

Affiliation Department of Bariatric and Metabolic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
⨯
Baoqin Yang,

Roles Methodology

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Zeng Yan,

Roles Methodology

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Yong Shen,

Roles Methodology

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Hui Qin,

Roles Investigation

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Li Chen,

Roles Investigation

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Tiantian Chen,

Roles Investigation

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Jigui Chen,

Roles Validation

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Shaihong Zhu,

Roles Validation

Affiliation Department of Bariatric and Metabolic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
⨯
Fei Xiong ,

Contributed equally to this work with: Fei Xiong, Xulong Sun

Roles Conceptualization, Writing – review & editing

* E-mail: brrhsyxndx@163.com (XS); feixiongg@foxmail.com (FX)

Affiliation Bariatric and Metabolic Medicine Center, The Eighth Hospital of Wuhan, Wuhan, China
⨯
Xulong Sun

Contributed equally to this work with: Fei Xiong, Xulong Sun

Roles Conceptualization, Writing – review & editing

* E-mail: brrhsyxndx@163.com (XS); feixiongg@foxmail.com (FX)

Affiliation Department of Bariatric and Metabolic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China

https://orcid.org/0009-0009-1586-7292

⨯

Global temporal trends and projections of gastroesophageal reflux disease prevalence: Age-period-cohort analysis 2021

Feng Xie,
Baoqin Yang,
Zeng Yan,
Yong Shen,
Hui Qin,
Li Chen,
Tiantian Chen,
Jigui Chen,
Shaihong Zhu,
Fei Xiong

Published: November 5, 2025
https://doi.org/10.1371/journal.pone.0334396

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