SF3B1^K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genes

• Mahtab Dastpak ,

  Contributed equally to this work with: Mahtab Dastpak, Claudia A. Mimoso

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Cell Line and Cell Bank Development, Mammalian Platform, CMC, Sanofi, Framingham, Massachussetts, USA

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

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• Claudia A. Mimoso ,

  Contributed equally to this work with: Mahtab Dastpak, Claudia A. Mimoso

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Current address: Yale School of Medicine, Department of Genetics, New Haven, Connecticut, USA

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachussetts, United States of America

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• Moein Farshchian,

  Roles Formal analysis, Writing – review & editing

  Affiliation Division of Oncology, Laboratory of Cellular Therapy, Department of Medical and Surgical Sciences for Children & Adults, University-Hospital of Modena and Reggio Emilia, Modena, Italy

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• Christina L. Paraggio,

  Roles Investigation, Writing – review & editing

  Current address: Yale School of Medicine, Department of Microbial Pathogenesis, New Haven, Connecticut, USA

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

  https://orcid.org/0000-0001-8515-3126

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• Claudia E. Leonard,

  Roles Investigation, Writing – review & editing

  Current address: Stanford University School of Medicine, Stanford, California, USA

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

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• Shanye Yin,

  Roles Investigation, Writing – review & editing

  Current address: Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

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• Binkai Chi,

  Roles Investigation, Writing – review & editing

  Current address: Leverna Therapeutics, Woburn, Massachussetts, USA

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

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• Kelsey W. Nassar,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

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• R. Grant Rowe,

  Roles Conceptualization, Methodology, Project administration, Resources, Writing – review & editing

  Affiliations Boston Children’s Hospital, Harvard Medical School, Boston, Massachussetts, United States of America, Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Boston, Massachussetts, United States of America

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• Jiuchun Zhang,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

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• Zhonggang Hou,

  Roles Investigation, Writing – review & editing

  Current address: Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

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• George Q. Daley,

  Roles Conceptualization, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Boston, Massachussetts, United States of America

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• Karen Adelman ,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: karen_adelman@hms.harvard.edu

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachussetts, United States of America

  https://orcid.org/0000-0001-5364-334X

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• Robin Reed

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Visualization, Writing – original draft

  ¶† Passed away in July 23, 2022.

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachussetts, United States of America

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