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Open Access
Peer-reviewed
Research Article
In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen – 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima
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Nirwani N. Seneviratne ,
Contributed equally to this work with: Nirwani N. Seneviratne, Tolulope P. Saliu, Fathima T. Muhinudeen, Sanadie D. Gamage
Roles Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Tolulope P. Saliu ,
Contributed equally to this work with: Nirwani N. Seneviratne, Tolulope P. Saliu, Fathima T. Muhinudeen, Sanadie D. Gamage
Roles Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Fathima T. Muhinudeen ,
Contributed equally to this work with: Nirwani N. Seneviratne, Tolulope P. Saliu, Fathima T. Muhinudeen, Sanadie D. Gamage
Roles Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Sanadie D. Gamage ,
Contributed equally to this work with: Nirwani N. Seneviratne, Tolulope P. Saliu, Fathima T. Muhinudeen, Sanadie D. Gamage
Roles Data curation, Software
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Prabudhi S. Garusinghe ,
Roles Data curation, Methodology, Software
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Damith Chathuranga ,
Roles Data curation, Software
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Vinoda D. Athukorala ,
Roles Data curation, Software
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Ashein Kothalawala ,
Roles Data curation, Software
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Asirini H. Jayasekara ,
Roles Data curation
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Rajitha K. Rathnayaka ,
Roles Data curation
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Umanda Anjalee De Silva ,
Roles Data curation
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Mohamed Faries ,
Roles Data curation
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Thimali H. Weragoda ,
Roles Data curation
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Shalini K. Wijerathne ,
Roles Data curation
¶‡ These authors also contributed equally to this work.
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Umapriyatharshini Rajagopalan,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Kanishka S. Senathilake ,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing
* E-mail: kanishka@ibmbb.cmb.ac.lk (KSS); achyut.adhikari@cdc.tu.edu.np (AA)
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Kamani H. Tennekoon,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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Achyut Adhikari ,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft
* E-mail: kanishka@ibmbb.cmb.ac.lk (KSS); achyut.adhikari@cdc.tu.edu.np (AA)
Affiliation Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal
⨯ - [ ... ],
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Sameera R. Samarakoon
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing
Affiliation Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka
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In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen – 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima
- Nirwani N. Seneviratne,
- Tolulope P. Saliu,
- Fathima T. Muhinudeen,
- Sanadie D. Gamage,
- Prabudhi S. Garusinghe,
- Damith Chathuranga,
- Vinoda D. Athukorala,
- Ashein Kothalawala,
- Asirini H. Jayasekara,
- Rajitha K. Rathnayaka
- Published: November 3, 2025
- https://doi.org/10.1371/journal.pone.0334238