Gardenia jasminoides fruit extract ameliorates non-alcoholic steatohepatitis with fibrosis by modulating inflammatory and fibrogenic pathways

Natnicha Suttawong; Namthip Witayavanitkul; Maneerat Chayanupatkul; Natcha Wanpiyarat; Pornpen Werawatganone; Prasong Siriviriyakul; Duangporn Werawatganon

doi:10.1371/journal.pone.0333800

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Open Access

Peer-reviewed

Research Article

Gardenia jasminoides fruit extract ameliorates non-alcoholic steatohepatitis with fibrosis by modulating inflammatory and fibrogenic pathways

Natnicha Suttawong,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Namthip Witayavanitkul ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

* E-mail: namthip.wi@chula.ac.th

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0003-3588-3766

⨯
Maneerat Chayanupatkul,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Natcha Wanpiyarat,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0003-3330-8186

⨯
Pornpen Werawatganone,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
⨯
Prasong Siriviriyakul,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Duangporn Werawatganon

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯

Gardenia jasminoides fruit extract ameliorates non-alcoholic steatohepatitis with fibrosis by modulating inflammatory and fibrogenic pathways

Natnicha Suttawong,
Namthip Witayavanitkul,
Maneerat Chayanupatkul,
Natcha Wanpiyarat,
Pornpen Werawatganone,
Prasong Siriviriyakul,
Duangporn Werawatganon

Published: October 3, 2025
https://doi.org/10.1371/journal.pone.0333800

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