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Open Access
Peer-reviewed
Research Article
HLF gene is a poor prognostic factor in acute myeloid leukemia patients with FLT3-ITD/NPM1 mutations undergoing hematopoietic transplantation
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Xiaoyu Xu ,
Contributed equally to this work with: Xiaoyu Xu, Xinxin Ge
Roles Data curation, Funding acquisition, Writing – original draft, Writing – review & editing
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Xinxin Ge ,
Contributed equally to this work with: Xiaoyu Xu, Xinxin Ge
Roles Funding acquisition, Methodology, Writing – original draft, Writing – review & editing
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Airui Jiang,
Roles Methodology
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Jia Chen,
Roles Methodology
Affiliations Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China, Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, Suzhou, China
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Qiaocheng Qiu,
Roles Methodology
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Zixuan Ding,
Roles Methodology
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Mingqing Zhu,
Roles Methodology
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Jinlan Pan,
Roles Methodology
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Zixing Chen,
Roles Methodology
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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Wenwen Du,
Roles Funding acquisition, Methodology
Affiliation Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Soochow University, Suzhou, China
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Depei Wu,
Roles Investigation, Methodology
Affiliations Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China, Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, Suzhou, China
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Suning Chen ,
Roles Investigation, Methodology, Writing – review & editing
* E-mail: chensuning@suda.edu.cn (SC); shenhongjie@suda.edu.cn (HS)
Affiliations Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China, Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, Suzhou, China
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Hongjie Shen
Roles Conceptualization, Investigation, Writing – review & editing
* E-mail: chensuning@suda.edu.cn (SC); shenhongjie@suda.edu.cn (HS)
Affiliation Jiangsu Institute of Hematology, National Center of Hematological Clinical Medicine Research, NHC Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China
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HLF gene is a poor prognostic factor in acute myeloid leukemia patients with FLT3-ITD/NPM1 mutations undergoing hematopoietic transplantation
- Xiaoyu Xu,
- Xinxin Ge,
- Airui Jiang,
- Jia Chen,
- Qiaocheng Qiu,
- Zixuan Ding,
- Mingqing Zhu,
- Jinlan Pan,
- Zixing Chen,
- Wenwen Du
- Published: October 14, 2025
- https://doi.org/10.1371/journal.pone.0333690