Exploring β-catenin and TCF4 interaction in complex environments by means of novel biosensing platform focal molography

Philipp Cedro; Roman Popov; Maxime Karrer; Jean-Christophe Hau; Eric-André Kusznir; Ralf Thoma; Andreas Frutiger; Matthias Lauer; Sylwia Huber

doi:10.1371/journal.pone.0333554

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Open Access

Peer-reviewed

Research Article

Exploring β-catenin and TCF4 interaction in complex environments by means of novel biosensing platform focal molography

Philipp Cedro ,

Roles Conceptualization, Investigation, Methodology, Resources, Writing – original draft

* E-mail: philipp.cedro@roche.com

Affiliation Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

https://orcid.org/0009-0005-9108-0708

⨯
Roman Popov,

Roles Methodology, Writing – review & editing

Affiliation Lino Biotech Ltd., Adliswil, Switzerland
⨯
Maxime Karrer,

Roles Methodology, Resources

Affiliation Roche Pharma Research and Early Development, DTA Oncology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Jean-Christophe Hau,

Roles Methodology, Writing – review & editing

Affiliation Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Eric-André Kusznir,

Roles Investigation

Affiliation Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Ralf Thoma,

Roles Resources

Affiliation Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Andreas Frutiger,

Roles Methodology, Software, Writing – review & editing

Affiliation Lino Biotech Ltd., Adliswil, Switzerland

https://orcid.org/0000-0002-2523-8918

⨯
Matthias Lauer,

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯
Sylwia Huber

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
⨯

Exploring β-catenin and TCF4 interaction in complex environments by means of novel biosensing platform focal molography

Philipp Cedro,
Roman Popov,
Maxime Karrer,
Jean-Christophe Hau,
Eric-André Kusznir,
Ralf Thoma,
Andreas Frutiger,
Matthias Lauer,
Sylwia Huber

Published: September 30, 2025
https://doi.org/10.1371/journal.pone.0333554

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Binding analysis
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