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Open Access

Peer-reviewed

Research Article

KIF18A induces the EMT process of hepatoma cells through the 5-LOX-dependent arachidonic acid pathway

Yibo Wang,

Roles Writing – original draft

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Tao Cai,

Roles Data curation, Formal analysis

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Yajie Chen,

Roles Investigation, Methodology

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Wenpeng Liu,

Roles Investigation, Methodology

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Baowang Liu,

Roles Resources

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Xin Zhao,

Roles Resources, Software

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Yang Wang,

Roles Validation, Visualization

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Jinglin Cao,

Roles Supervision

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
⨯
Qiang Zeng

Roles Funding acquisition, Writing – review & editing

* E-mail: zengqiang457@hebmu.edu.cn

Affiliation Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China

https://orcid.org/0000-0002-0973-580X

⨯

KIF18A induces the EMT process of hepatoma cells through the 5-LOX-dependent arachidonic acid pathway

Yibo Wang,
Tao Cai,
Yajie Chen,
Wenpeng Liu,
Baowang Liu,
Xin Zhao,
Yang Wang,
Jinglin Cao,
Qiang Zeng

x

Published: October 13, 2025
https://doi.org/10.1371/journal.pone.0333385

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Hepatocellular carcinoma
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Gene expression
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Transfection
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Cancer cell migration
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Metabolic pathways
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Genetic screens
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Protein interaction networks
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Prognosis
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