Exploring local adjuvant antibiotics as viable alternative to systemic antibiotics in non-surgical periodontal therapy: Clinical, immunological and microbiological insights

Iva Milinkovic; Marija Vuckovic; Nadja Nikolic; Jelena Carkic; Zoran Aleksic; Sasha Jankovic; Jelena Milasin; Ana Djinic Krasavcevic

doi:10.1371/journal.pone.0333342

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Open Access

Peer-reviewed

Research Article

Exploring local adjuvant antibiotics as viable alternative to systemic antibiotics in non-surgical periodontal therapy: Clinical, immunological and microbiological insights

Iva Milinkovic,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliations Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia, Implant-Research Centre, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0001-5664-7848

⨯
Marija Vuckovic,

Roles Data curation, Investigation

Affiliation Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0003-1379-6717

⨯
Nadja Nikolic,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Implant-Research Centre, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0002-8513-9313

⨯
Jelena Carkic,

Roles Data curation, Investigation

Affiliation Implant-Research Centre, School of Dental Medicine, University of Belgrade, Belgrade, Serbia
⨯
Zoran Aleksic,

Roles Funding acquisition, Resources, Validation

Affiliations Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia, Implant-Research Centre, School of Dental Medicine, University of Belgrade, Belgrade, Serbia
⨯
Sasha Jankovic,

Roles Funding acquisition, Supervision

Affiliation Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia
⨯
Jelena Milasin,

Roles Conceptualization, Supervision

Affiliation Implant-Research Centre, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0002-6225-7210

⨯
Ana Djinic Krasavcevic

Roles Investigation, Methodology, Writing – original draft

* E-mail: ana.djinic@gmail.com

Affiliation Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0001-9439-0529

⨯

Exploring local adjuvant antibiotics as viable alternative to systemic antibiotics in non-surgical periodontal therapy: Clinical, immunological and microbiological insights

Iva Milinkovic,
Marija Vuckovic,
Nadja Nikolic,
Jelena Carkic,
Zoran Aleksic,
Sasha Jankovic,
Jelena Milasin,
Ana Djinic Krasavcevic

Published: September 29, 2025
https://doi.org/10.1371/journal.pone.0333342

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Periodontitis
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