SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway

• Tianyu Wu,

  Roles Investigation, Methodology, Writing – original draft

  Affiliations Department of Urology, Peking University First Hospital, Beijing, China, Institution of Urology, Peking University, Beijing, China, Beijing Key Laboratory of Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center, Beijing, China, National Urological Cancer Center, Beijing, China

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• Xing Ji,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliations Department of Urology, Peking University First Hospital, Beijing, China, Institution of Urology, Peking University, Beijing, China, Beijing Key Laboratory of Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center, Beijing, China, National Urological Cancer Center, Beijing, China

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• Yongyang Yun,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliations Department of Urology, Peking University First Hospital, Beijing, China, Institution of Urology, Peking University, Beijing, China, Beijing Key Laboratory of Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center, Beijing, China, National Urological Cancer Center, Beijing, China

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• Xiaofei Wang,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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• Ying Gan,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  Affiliations Department of Urology, Peking University First Hospital, Beijing, China, Institution of Urology, Peking University, Beijing, China, Beijing Key Laboratory of Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center, Beijing, China, National Urological Cancer Center, Beijing, China

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• Yu Fan,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Urology, Peking University First Hospital, Beijing, China, Institution of Urology, Peking University, Beijing, China, Beijing Key Laboratory of Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center, Beijing, China, National Urological Cancer Center, Beijing, China

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• Qian Zhang

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: ueyr847@outlook.com

  Affiliation Department of Urology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China

  https://orcid.org/0009-0003-0713-313X

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