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Open Access

Peer-reviewed

Research Article

Therapeutic mechanism of Pithecellobium clypearia Benth. on imiquimod-induced psoriasis revealed by tissue transcriptomics in mice

Xiyuan He,

Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Yueting Mo,

Roles Software, Visualization, Writing – original draft

Affiliation Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Peixin Shi,

Roles Visualization, Writing – original draft

Affiliation Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Yini Xu,

Roles Visualization, Writing – original draft

Affiliation State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China
⨯
Mingmei Zhou,

Roles Conceptualization

Affiliation Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Ting Zhang

Roles Conceptualization, Writing – review & editing

^* zhtcpu@163.com

Affiliations Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China

https://orcid.org/0009-0004-1934-8493

⨯

Therapeutic mechanism of Pithecellobium clypearia Benth. on imiquimod-induced psoriasis revealed by tissue transcriptomics in mice

Xiyuan He,
Yueting Mo,
Peixin Shi,
Yini Xu,
Mingmei Zhou,
Ting Zhang

x

Published: December 12, 2025
https://doi.org/10.1371/journal.pone.0333197

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Psoriasis
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Inflammation
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MAPK signaling cascades
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Gene expression
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Apoptosis
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Hedgehog signaling
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RNA sequencing
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Mitochondria
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