Efficacy of prophylactic tranexamic acid among parturient at increased risk for postpartum hemorrhage undergoing cesarean delivery: A systematic review and meta-analyses of randomized controlled trials

Mohamed Aziz Daghmouri; Simon Crequit; Amelie Madeuf; Wael Chaabane; Ortéga Laurent; Patrick Lafforgue; Bechir Azzouzi; Ines Ouaz; Mohamed Ali Chaouch

doi:10.1371/journal.pone.0333177

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Open Access

Peer-reviewed

Research Article

Efficacy of prophylactic tranexamic acid among parturient at increased risk for postpartum hemorrhage undergoing cesarean delivery: A systematic review and meta-analyses of randomized controlled trials

Mohamed Aziz Daghmouri ,

Roles Conceptualization, Methodology, Project administration, Validation, Writing – original draft

* E-mail: aziz.daghmouri@gmail.fr

Affiliation Department of Anesthesia, Montreuil Intercommunal Hospital Center, Montreuil, France

https://orcid.org/0000-0001-5648-5834

⨯
Simon Crequit,

Roles Validation, Writing – review & editing

Affiliation Department of Gynecology, Montreuil Intercommunal Hospital Center, Montreuil, France
⨯
Amelie Madeuf,

Roles Validation, Writing – review & editing

Affiliation Department of Gynecology, Perpignan Hospital Center, Perpignan, France
⨯
Wael Chaabane,

Roles Validation, Writing – review & editing

Affiliation Department of Emergency, Perpignan Hospital Center, Perpignan, France
⨯
Ortéga Laurent,

Roles Validation, Writing – review & editing

Affiliation Department of Emergency, Perpignan Hospital Center, Perpignan, France
⨯
Patrick Lafforgue,

Roles Validation, Writing – review & editing

Affiliation Department of Emergency, Perpignan Hospital Center, Perpignan, France
⨯
Bechir Azzouzi,

Roles Validation, Writing – review & editing

Affiliation Department of Emergency, Perpignan Hospital Center, Perpignan, France
⨯
Ines Ouaz,

Roles Validation, Writing – review & editing

Affiliation Department of Emergency, Perpignan Hospital Center, Perpignan, France
⨯
Mohamed Ali Chaouch

Roles Conceptualization, Formal analysis, Validation, Writing – original draft

Affiliation Department of Visceral and Digestive Surgery, Monastir University Hospital, Monastir, Tunisia
⨯

Efficacy of prophylactic tranexamic acid among parturient at increased risk for postpartum hemorrhage undergoing cesarean delivery: A systematic review and meta-analyses of randomized controlled trials

Mohamed Aziz Daghmouri,
Simon Crequit,
Amelie Madeuf,
Wael Chaabane,
Ortéga Laurent,
Patrick Lafforgue,
Bechir Azzouzi,
Ines Ouaz,
Mohamed Ali Chaouch

Published: October 9, 2025
https://doi.org/10.1371/journal.pone.0333177

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Postpartum hemorrhage
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Medical risk factors
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Blood transfusion
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Cesarean section
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Metaanalysis
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Prophylaxis
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Randomized controlled trials
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Systematic reviews
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