QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults

Yuichi Ninomiya; Kei Enokizono; Shin Kawasoe; Takuro Kubozono; Hiroyuki Kamada; Yasuhisa Iriki; Yoshiyuki Ikeda; Hironori Miyahara; Koichi Tokushige; Mitsuru Ohishi

doi:10.1371/journal.pone.0333169

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Open Access

Peer-reviewed

Research Article

QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults

Yuichi Ninomiya ,

Roles Conceptualization, Data curation, Writing – review & editing

* E-mail: yuichi-n@kbf.biglobe.ne.jp

Affiliations Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Department of Cardiovascular Medicine, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan

https://orcid.org/0000-0002-1618-9739

⨯
Kei Enokizono,

Roles Writing – original draft

Affiliation Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Shin Kawasoe,

Roles Project administration

Affiliation Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Takuro Kubozono,

Roles Supervision

Affiliation Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Hiroyuki Kamada,

Roles Validation

Affiliation Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Yasuhisa Iriki,

Roles Data curation

Affiliation Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Yoshiyuki Ikeda,

Roles Supervision

Affiliation Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯
Hironori Miyahara,

Roles Resources

Affiliation Kagoshima Kouseiren Hospital, Kagoshima, Japan
⨯
Koichi Tokushige,

Roles Resources

Affiliation Kagoshima Kouseiren Hospital, Kagoshima, Japan
⨯
Mitsuru Ohishi

Roles Supervision

Affiliation Department of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
⨯

QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults

Yuichi Ninomiya,
Kei Enokizono,
Shin Kawasoe,
Takuro Kubozono,
Hiroyuki Kamada,
Yasuhisa Iriki,
Yoshiyuki Ikeda,
Hironori Miyahara,
Koichi Tokushige,
Mitsuru Ohishi

Published: October 22, 2025
https://doi.org/10.1371/journal.pone.0333169

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Atrial fibrillation
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Obesity
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Electrocardiography
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