Genetic drivers of liver cirrhosis: The role of SERPINA1 and PNPLA3 variants in disease onset and progression

• Mikolas Holinka,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Third Faculty of Medicine, Charles University, Prague, Czech Republic

  https://orcid.org/0009-0007-2353-5189

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• Sona Frankova ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

  * E-mail: sona.frankova@ikem.cz

  Affiliation Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

  https://orcid.org/0000-0002-1462-5920

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• Svetlana Adamcova Selcanova,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation HEGITO—Department of Hepatology, Gastroenterology and Liver Transplantation of 2nd Department of Internal Medicine, F. D. Roosevelt University Hospital, Banska Bystrica, Slovakia

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• Lubomir Skladany,

  Roles Conceptualization, Data curation, Investigation, Project administration, Writing – original draft, Writing – review & editing

  Affiliations HEGITO—Department of Hepatology, Gastroenterology and Liver Transplantation of 2nd Department of Internal Medicine, F. D. Roosevelt University Hospital, Banska Bystrica, Slovakia, 2nd Department of Internal Medicine, L. Pasteur University Hospital and P. J. Safarik University, Kosice, Slovakia

  https://orcid.org/0000-0001-5171-3623

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• Ondrej Fabian,

  Roles Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Clinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic

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• Martin Kveton,

  Roles Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Third Faculty of Medicine, Charles University, Prague, Czech Republic, Clinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

  https://orcid.org/0000-0002-8627-8059

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• Dusan Merta,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Anaesthesiology and Resuscitation Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, First Faculty of Medicine, Charles University, Prague, Czech Republic

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• Vera Adamkova,

  Roles Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Preventive Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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• Jaroslav A. Hubacek,

  Roles Data curation, Investigation, Project administration, Writing – review & editing

  Affiliation Atherosclerosis Research Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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• Veronika Pitova,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, First Faculty of Medicine, Charles University, Prague, Czech Republic

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• Sarka Vesela,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations First Faculty of Medicine, Charles University, Prague, Czech Republic, Laboratory of Experimental Hepatology, Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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• Tomas Hucl,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, First Faculty of Medicine, Charles University, Prague, Czech Republic

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• Milan Jirsa,

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations First Faculty of Medicine, Charles University, Prague, Czech Republic, Laboratory of Experimental Hepatology, Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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• Jan Sperl

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, First Faculty of Medicine, Charles University, Prague, Czech Republic

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