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Open Access
Peer-reviewed
Research Article
Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice impacts adipokine secretion, plasma free fatty acids, and improves cerebrovascular health
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Florine Seidel,
Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department Medical Imaging, Anatomy, Preclinical Imaging Center, Radboud Alzheimer Center, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen, The Netherlands, Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Martine C. Morrison,
Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Ilse Arnoldussen,
Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department Medical Imaging, Anatomy, Preclinical Imaging Center, Radboud Alzheimer Center, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen, The Netherlands
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Vivienne Verweij,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Department Medical Imaging, Anatomy, Preclinical Imaging Center, Radboud Alzheimer Center, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen, The Netherlands
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Simon Ebert,
Roles Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany
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Joline Attema,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Christa de Ruiter,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Wim van Duyvenvoorde,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Jessica Snabel,
Roles Writing – original draft, Writing – review & editing
Affiliation Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Bram Geenen,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Department Medical Imaging, Anatomy, Preclinical Imaging Center, Radboud Alzheimer Center, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen, The Netherlands
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Ayla Franco,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Department Medical Imaging, Anatomy, Preclinical Imaging Center, Radboud Alzheimer Center, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen, The Netherlands
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Eveline Gart,
Roles Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Jürgen Bernhagen,
Roles Formal analysis, Writing – original draft, Writing – review & editing
Affiliations Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany, German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
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Maximilian Wiesmann,
Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department Medical Imaging, Anatomy, Preclinical Imaging Center, Radboud Alzheimer Center, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen, The Netherlands
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Robert Kleemann ,
Contributed equally to this work with: Robert Kleemann, Amanda J. Kiliaan
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, The Netherlands
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Amanda J. Kiliaan
Contributed equally to this work with: Robert Kleemann, Amanda J. Kiliaan
Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: amanda.kiliaan@radboudumc.nl
Affiliation Department Medical Imaging, Anatomy, Preclinical Imaging Center, Radboud Alzheimer Center, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen, The Netherlands
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Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice impacts adipokine secretion, plasma free fatty acids, and improves cerebrovascular health
- Florine Seidel,
- Martine C. Morrison,
- Ilse Arnoldussen,
- Vivienne Verweij,
- Simon Ebert,
- Joline Attema,
- Christa de Ruiter,
- Wim van Duyvenvoorde,
- Jessica Snabel,
- Bram Geenen
- Published: October 17, 2025
- https://doi.org/10.1371/journal.pone.0333024